The third OPATHY annual meeting and summer school took place from 26th of August to 1st of September 2018 at the University of Valencia Science Park, in Paterna, Spain and was organised by the OPATHY project partner Biotechvana. With a focus on applied bioinformatics and post-genomics techniques for clinical omics, ESRs received intense theoretical and practical training in varous aspects of bioinformatic analyses, e.g. in using the GPRO software suite that was developed at Biotechvana. Lectures of the summer school furthermore comprised ethical aspects of the use of human and animal samples in clinical research as well as good practice in scientific publishing.